Classification and application of metal-based nanoantioxidants in medicine and healthcare

• Nguyen Nhat Nam,
• Nguyen Khoi Song Tran,
• Tan Tai Nguyen,
• Nguyen Ngoc Trai,
• Nguyen Phuong Thuy,
• Hoang Dang Khoa Do,
• Nhu Hoa Thi Tran and
• Kieu The Loan Trinh

Beilstein J. Nanotechnol. 2024, 15, 396–415, doi:10.3762/bjnano.15.36

• natural and synthetic nanocarriers. Because of the advantages of synthetic nanocarriers regarding easier customization of size, surface properties, charge, and morphology, we will focus on synthetic nanocarriers. Various types of synthetic nanocarriers have been developed to deliver natural antioxidants

• radicals, preventing oxidative stress and cellular damage thanks to their diverse size and surface properties. Administering platinum NPs to transient middle cerebral artery occlusion (tMCAO) mice significantly decreased the infarct volume, matrix metalloproteinase-9 (MMP-9) activation, and the generation

Multiscale modelling of biomolecular corona formation on metallic surfaces

• Parinaz Mosaddeghi Amini,
• Ian Rouse,
• Julia Subbotina and
• Vladimir Lobaskin

Beilstein J. Nanotechnol. 2024, 15, 215–229, doi:10.3762/bjnano.15.21

• surfaces and nanoparticles after packaging. The figure was created with BioRender.com, https://biorender.com/. This content is not subject to CC BY 4.0. A chart of the main factors determining the structure of the bionano interface. The quantitative model comprises three essential aspects, that is, surface

• properties of the nanomaterial, the characteristics of the surrounding medium, and the biological factors at play. A dataflow scheme of the multiscale modelling approach implemented in this study, including an all-atom model of surface and AAs, a CG UnitedAtom model for the entire protein-surface interaction

Fluorescent bioinspired albumin/polydopamine nanoparticles and their interactions with Escherichia coli cells

• Eloïse Equy,
• Jordana Hirtzel,
• Sophie Hellé,
• Béatrice Heurtault,
• Eric Mathieu,
• Morgane Rabineau,
• Vincent Ball and
• Lydie Ploux

Beilstein J. Nanotechnol. 2023, 14, 1208–1224, doi:10.3762/bjnano.14.100

• of a E. coli population (Figure 6a). This was maintained regardless of the surface properties of the NPs since pristine, Ox-, and RhBITC-BSA/PDA NPs all failed to inhibit E. coli growth (Figure 7b). It can be noted that the population growth was even slightly but significantly favored in the presence

Curcumin-loaded albumin submicron particles with potential as a cancer therapy: an in vitro study

• Nittiya Suwannasom,
• Netsai Sriaksorn,
• Chutamas Thepmalee,
• Krissana Khoothiam,
• Ausanai Prapan,
• Hans Bäumler and
• Chonthida Thephinlap

Beilstein J. Nanotechnol. 2023, 14, 1127–1140, doi:10.3762/bjnano.14.93

• cancer cells, likely attributed to particle uptake through endocytosis pathways, including phagocytosis and macropinocytosis [51]. The uptake process depends on cell membrane and particle properties, including size, shape, composition, and surface properties. These factors play a crucial role in particle

Recognition mechanisms of hemoglobin particles by monocytes – CD163 may just be one

• Jonathan-Gabriel Nimz,
• Pichayut Rerkshanandana,
• Chiraphat Kloypan,
• Ulrich Kalus,
• Saranya Chaiwaree,
• Axel Pruß,
• Radostina Georgieva,
• Yu Xiong and
• Hans Bäumler

Beilstein J. Nanotechnol. 2023, 14, 1028–1040, doi:10.3762/bjnano.14.85

• occur in the liver [24][25][26]. The question of the mechanisms by which HBOCs are sequestered remains partly unclear though. Possible degradation pathways include haptoglobin (Hp), which, depending on the size and surface properties of HBOCs, could bind its physiological target protein hemoglobin [16

Nanoarchitectonics of photothermal materials to enhance the sensitivity of lateral flow assays

• Elangovan Sarathkumar,
• Rajasekharan S. Anjana and
• Ramapurath S. Jayasree

Beilstein J. Nanotechnol. 2023, 14, 988–1003, doi:10.3762/bjnano.14.82

• sensitivity is an important research area. The nanoscale architecture, including shape, size, composition, and surface properties, is expected to play a major role in the photothermal properties of nanomaterials [26]. The nanoscale architecture is not only responsible for the optical characteristics of the

Antibody-conjugated nanoparticles for target-specific drug delivery of chemotherapeutics

• Mamta Kumari,
• Amitabha Acharya and
• Praveen Thaggikuppe Krishnamurthy

Beilstein J. Nanotechnol. 2023, 14, 912–926, doi:10.3762/bjnano.14.75

• increased the binding affinity of the NPs to bind to the Zika virus NS1 [84]. In contrast, Dai et al. examined the effect of protein corona formation on the targeting ability of silica-poly(methacrylic acid)-PEG-AntiHER2 NPs. They demonstrated that a protein corona from human serum affects the NPs surface

• properties by reducing surface charge and availability of conjugated molecules on the NPs, which results in a reduction of targeting capacity from 70% to 7%. However, HAS-incubated NPs exhibited increased interaction between targeting molecule and ligand, boosting the targeting capacity of Afb-conjugated NPs

Biomimetics on the micro- and nanoscale – The 25th anniversary of the lotus effect

• Matthias Mail,
• Kerstin Koch,
• Thomas Speck,
• William M. Megill and
• Stanislav N. Gorb

Beilstein J. Nanotechnol. 2023, 14, 850–856, doi:10.3762/bjnano.14.69

• processes by the authors. They looked to a seemingly unrelated archetype, the xylem system of trees, which uses pits instead of extrusions to create its surface properties. This led the team to a new approach and eventually to a successful product. The authors present the case study as a reminder that the

• along its body. The authors built on this inspiration to develop carbon nanotube cones which similarly separate the regions. Their model predicts the specific geometry and surface properties that will be required to create a low-pressure system for harvesting water vapour. Rebora et al. [19], in the

Silver nanoparticles loaded on lactose/alginate: in situ synthesis, catalytic degradation, and pH-dependent antibacterial activity

• Nguyen Thi Thanh Tu,
• T. Lan-Anh Vo,
• T. Thu-Trang Ho,
• Kim-Phuong T. Dang,
• Van-Dung Le,
• Phan Nhat Minh,
• Chi-Hien Dang,
• Vinh-Thien Tran,
• Van-Su Dang,
• Tran Thi Kim Chi,
• Hieu Vu-Quang,
• Radek Fajgar,
• Thi-Lan-Huong Nguyen,
• Van-Dat Doan and
• Thanh-Danh Nguyen

Beilstein J. Nanotechnol. 2023, 14, 781–792, doi:10.3762/bjnano.14.64

• catalytic performance in degrading the pollutants methyl orange and rhodamine B. The antibacterial activity of the nanocomposite is pH-dependent, related to the alterations in surface properties of the nanocomposite at different pH values. At pH 6, the nanocomposite demonstrated the highest antibacterial

• surface properties of silver nanoparticles. The highest bioactivity was observed at pH 6. These findings suggest that the nanocomposite may be customized for specific applications in environmental and medicinal treatments, making it a promising material. Experimental Materials The following chemicals and

Cross-sectional Kelvin probe force microscopy on III–V epitaxial multilayer stacks: challenges and perspectives

• Mattia da Lisca,
• José Alvarez,
• James P. Connolly,
• Nicolas Vaissiere,
• Karim Mekhazni,
• Jean Decobert and
• Jean-Paul Kleider

Beilstein J. Nanotechnol. 2023, 14, 725–737, doi:10.3762/bjnano.14.59

• enhancing device efficiency [10][11]. Consequently, the experimental demonstration of the sensitivity of KPFM to the narrower layers can be crucial for the investigation and comprehension of local surface properties and charge transport mechanisms at interfaces [12]. Within this context, this work presents

Metal-organic framework-based nanomaterials as opto-electrochemical sensors for the detection of antibiotics and hormones: A review

• Akeem Adeyemi Oladipo,
• Saba Derakhshan Oskouei and
• Mustafa Gazi

Beilstein J. Nanotechnol. 2023, 14, 631–673, doi:10.3762/bjnano.14.52

• extremely low densities (0.1–1 g·cm−3), the highest specific surface areas (165–7800 m2·g−1) currently known, tunable surface properties, good mechanical and thermal stability, intriguing and controllable morphologies, and uniform yet tunable pores that are created by the self-assembly of metal ions or

Nanoarchitectonics to entrap living cells in silica-based systems: encapsulations with yolk–shell and sepiolite nanomaterials

• Celia Martín-Morales,
• Jorge Fernández-Méndez,
• Pilar Aranda and
• Eduardo Ruiz-Hitzky

Beilstein J. Nanotechnol. 2023, 14, 522–534, doi:10.3762/bjnano.14.43

• for cancer treatment [31]. Results and Discussion Sepiolite–biopolymer microalgal biohybrids Sepiolite, a microfibrous hydrated magnesium silicate with the formula Si12O30Mg8(OH,F)4(H2O)4·8H2O [32][33][34], shows interesting surface properties and high viscosity [27][33][34][35]. These properties make

Biocatalytic synthesis and ordered self-assembly of silica nanoparticles via a silica-binding peptide

• Mustafa Gungormus

Beilstein J. Nanotechnol. 2023, 14, 280–290, doi:10.3762/bjnano.14.25

• monodisperse nanoparticles and to modify the surface properties to fully exploit the advantages offered by self-assembly. Biomolecules, such as peptides and proteins, have been demonstrated to be useful in the synthesis and self-assembly of inorganic nanostructures [15][16]. Herein, we have investigated the

High–low Kelvin probe force spectroscopy for measuring the interface state density

• Ryo Izumi,
• Masato Miyazaki,
• Yan Jun Li and
• Yasuhiro Sugawara

Beilstein J. Nanotechnol. 2023, 14, 175–189, doi:10.3762/bjnano.14.18

• that of the intrinsic semiconductor [19]. Thus, since the CPD is strongly affected by the surface properties, accurate evaluation of the surface state and bulk impurity concentration requires a method that extracts only the surface potential effect due to interface states. Recently, we proposed high

Non-stoichiometric magnetite as catalyst for the photocatalytic degradation of phenol and 2,6-dibromo-4-methylphenol – a new approach in water treatment

• Joanna Kisała,
• Anna Tomaszewska and
• Przemysław Kolek

Beilstein J. Nanotechnol. 2022, 13, 1531–1540, doi:10.3762/bjnano.13.126

• as possible photocatalysts. The morphology, optical properties, and structural properties of the M1 and M2 samples were investigated. The stoichiometry of magnetite noticeably impacted the optical and surface properties. Direct photolysis indicated that the bromine substituent facilitated the

Orally administered docetaxel-loaded chitosan-decorated cationic PLGA nanoparticles for intestinal tumors: formulation, comprehensive in vitro characterization, and release kinetics

• Sedat Ünal,
• Osman Doğan and
• Yeşim Aktaş

Beilstein J. Nanotechnol. 2022, 13, 1393–1407, doi:10.3762/bjnano.13.115

• literature, there are various studies showing consistency with our results. Varan et al. reported that cationic nanoparticles have a higher tendency to interact with the negatively charged cell membrane [67]. Accordingly, Verma et al. stated that the surface properties and charges of nanoparticles play an

Design of a biomimetic, small-scale artificial leaf surface for the study of environmental interactions

• Miriam Anna Huth,
• Axel Huth,
• Lukas Schreiber and
• Kerstin Koch

Beilstein J. Nanotechnol. 2022, 13, 944–957, doi:10.3762/bjnano.13.83

• wetting properties of a natural leaf surface. Keywords: recrystallization; surface properties; wax composition; wetting; wheat; Introduction Cuticle One of the largest interfaces on earth is formed by thin layers that are a few nanometers to micrometers thin, namely the wax layers of the plant cuticle

• physicochemical properties due to the cuticle and, in particular, due to the epicuticular waxes deposited on it. In previous studies, bio-inspired technical surfaces were often used with surface properties only partially corresponding to those of the natural surfaces. In the present work, an artificial leaf

• surface was developed that corresponded to the plant leaf surface in its chemical properties and its wettability. Wax morphology Natural surface First, the surface properties of the natural wheat leaf were characterized. For wheat leaves, platelets as well as tubules have been previously described as wax

Comparing the performance of single and multifrequency Kelvin probe force microscopy techniques in air and water

• Jason I. Kilpatrick,
• Emrullah Kargin and
• Brian J. Rodriguez

Beilstein J. Nanotechnol. 2022, 13, 922–943, doi:10.3762/bjnano.13.82

• of topography and surface properties of interfaces in a wide range of environments [1]. Kelvin probe force microscopy (KPFM) utilizes the application of a bias and a conductive probe to map the local electrical properties of an interface at the nanoscale [2], allowing for the determination of the

Bioselectivity of silk protein-based materials and their bio-inspired applications

• Hendrik Bargel,
• Vanessa T. Trossmann,
• Christoph Sommer and
• Thomas Scheibel

Beilstein J. Nanotechnol. 2022, 13, 902–921, doi:10.3762/bjnano.13.81

• of proteins, microbes, and cells should be guided by material-related surface properties to create bioinert, bioactive, or biomimetic biomaterials. 1.3 Antiadhesive and anti-fouling protein surfaces Nature has evolved a diverse portfolio of anti-adhesive, antimicrobial and antifouling methods

Antibacterial activity of a berberine nanoformulation

• Hue Thi Nguyen,
• Tuyet Nhung Pham,
• Anh-Tuan Le,
• Nguyen Thanh Thuy,
• Tran Quang Huy and
• Thuy Thi Thu Nguyen

Beilstein J. Nanotechnol. 2022, 13, 641–652, doi:10.3762/bjnano.13.56

• BBR NPs. The mean size of the particles measured by DLS was 156 nm for BBR NPs at a concentration of 2.0 mg/mL. The particle size measured by DLS was larger than the size obtained from TEM analysis because this dynamic measurement is affected by the concentration of the solution, surface properties of

Stimuli-responsive polypeptide nanogels for trypsin inhibition

• Petr Šálek,
• Jana Dvořáková,
• Sviatoslav Hladysh,
• Diana Oleshchuk,
• Ewa Pavlova,
• Jan Kučka and
• Vladimír Proks

Beilstein J. Nanotechnol. 2022, 13, 538–548, doi:10.3762/bjnano.13.45

• indicates that PHEG-Tyr nanogel is more solubilized at 25 °C than at 37 °C when the polymer–polymer interactions prevail [28]. The zeta potential of PHEG-Tyr nanogel was measured to determine the surface properties at different pH values and temperatures. Figure 2b shows that the zeta potential of PHEG-Tyr

Ciprofloxacin-loaded dissolving polymeric microneedles as a potential therapeutic for the treatment of S. aureus skin infections

• Sharif Abdelghany,
• Walhan Alshaer,
• Yazan Al Thaher,
• Maram Al Fawares,
• Amal G. Al-Bakri,
• Saja Zuriekat and
• Randa SH. Mansour

Beilstein J. Nanotechnol. 2022, 13, 517–527, doi:10.3762/bjnano.13.43

• ]. Gelatinous substances can interact with water, which allows one to control various physical, mechanical, and chemical properties of the artificial skin, such as hardness, and surface properties [24]. Therefore, agarose gel was utilized as artificial skin and was subsequently treated with inoculum of

Investigation of electron-induced cross-linking of self-assembled monolayers by scanning tunneling microscopy

• Patrick Stohmann,
• Sascha Koch,
• Yang Yang,
• Christopher David Kaiser,
• Julian Ehrens,
• Jürgen Schnack,
• Niklas Biere,
• Dario Anselmetti,
• Armin Gölzhäuser and
• Xianghui Zhang

Beilstein J. Nanotechnol. 2022, 13, 462–471, doi:10.3762/bjnano.13.39

• tailor surface properties [13][14][15][16][17][18][19][20]. These monolayers can be modified with lithographic tools, such as scanning probes [21], UV light, X-rays, ions, or electron beams [22][23][24]. A particularly versatile nanofabrication scheme utilizes electron irradiation of aromatic SAMs to

Investigation of a memory effect in a Au/(Ti–Cu)Ox-gradient thin film/TiAlV structure

• Damian Wojcieszak,
• Jarosław Domaradzki,
• Michał Mazur,
• Tomasz Kotwica and
• Danuta Kaczmarek

Beilstein J. Nanotechnol. 2022, 13, 265–273, doi:10.3762/bjnano.13.21

• of the current-to-voltage measurements. On the basis of the performed investigations, we suggest that the conducting filament switching is the most probable mechanism. This is supported by investigations of structure and surface properties using X-ray methods, UV photoelectron spectroscopy, and cross

• transitions using the Tauc method. Structure and elemental composition Surface properties The oxidation state of copper on the surface of (Ti0.48Cu0.52)Ox thin film was analyzed with the XPS Cu 2p core level spectrum (Figure 6). The Cu 2p core level has split spin–orbit components with ΔBE of 19.8 eV and an

Engineered titania nanomaterials in advanced clinical applications

• Padmavati Sahare,
• Paulina Govea Alvarez,
• Juan Manual Sanchez Yanez,
• Gabriel Luna-Bárcenas,
• Samik Chakraborty,
• Sujay Paul and
• Miriam Estevez

Beilstein J. Nanotechnol. 2022, 13, 201–218, doi:10.3762/bjnano.13.15

• corona alters the surface properties and transforms the physical, chemical, and biological characteristics of the nanomaterial. The types and amounts of adsorbed proteins are influenced by certain physiochemical qualities of the nanomaterial, such as the size, shape, charge as well as topography